Meningococcal Carriage among Household Contacts of Patients with Invasive Meningococcal Disease in Kathmandu, Nepal: A Longitudinal Study

Does eradication of meningococcal carriage in household contacts prevent secondary cases of meningococcal disease?

Comment Strains of meningococci carried in the general population usually belong to non-virulent serological groups and types, even during an epidemic, and hence the ratio of attacks to carriers is low3; in Denmark in 1987 it was 1:17000 (297 cases in a population of 5-1 million). If the secondary attack rate among household contacts of an index case of meningococcal disease is 500-800 times th...

Acquisition of W135 meningococcal carriage in Hajj pilgrims and transmission to household contacts: prospective study.

211-8. 14 Bartzokas CA, Gibson MF, Graham R, Pinder DC. A comparison of triclosan and chlorhexidine preparations with 60 per cent isopropyl alcohol for hygienic hand disinfection. J Hosp Infect 1983;4:245-55. 15 Ayliffe GAJ, Babb JR, Davies JG, Lilly HA. Hand disinfection: a comparison of various agents in laboratory and ward studies. J Hosp Infect 1988;11:226-43. 16 Zaragoza M, Sallés M, Gomez...

High Risk for Invasive Meningococcal Disease Among Patients Receiving Eculizumab (Soliris) Despite Receipt of Meningococcal Vaccine

Use of eculizumab (Soliris, Alexion Pharmaceuticals), a terminal complement inhibitor, is associated with a 1,000-fold to 2,000-fold increased incidence of meningococcal disease (1). Administration of meningococcal vaccines is recommended for patients receiving eculizumab before beginning treatment (2,3). Sixteen cases of meningococcal disease were identified in eculizumab recipients in the Uni...

Invasive meningococcal disease in childhood.

Surveillance of Invasive Meningococcal Disease

Invasive meningococcal disease (IMD) is a nationally reportable disease in Canada. Since 1985, the Laboratory Centre for Disease Control (LCDC) has enhanced IMD surveillance to correlate case-by-case information provided by the provinces and territories with detailed laboratory studies done at the National Laboratory for Bacteriology at LCDC. This report provides information on IMD from 1 Janua...